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- Title
Adenovirus type 36 seropositivity and levels of leptin, adiponectin, IL-6 in obese children.
- Authors
Dinç, Harika Öykü; Ergin, Sevgi; Yüksel, Pelin; Sarıbaş, Suat; Kocazeybek, Bekir S.; Evliyaoğlu, Olcay; Taşkın Özcabi, Bahar; Çizmecigil, Utku; Turan, Nuri; Yılmaz, Hüseyin; Çağatay, Penbe; Atalık, Kevser
- Abstract
Background: Obesity is the most important public health issue these days and infectious agents -especially Adenovirus 36 (Ad-36) - have recently emerged as a possible contributor to the current obesity epidemic. The number of studies about the alleged obesity pathogenesis that developed by adipose tissue Ad-36 trigger is increasing in both the child and adult. The aim of this study was to investigate the prevalence of Ad-36 antibodies in obese children and also investigate the relationship between ˝Ad-36-obesity˝ with the role of serum leptin, adiponectin, IL-6 and lipid levels. Materials & Method: In this cross-sectional and case-control based study, 71 obese children (BMI % ≥95) and 69 non-obese children (BMI % ≤80) were included in this study as patient group and healthy control group, respectively (age range: 7-17). Simultaneously, the peresence of Ad-36 antibodies and serum adipokine levels were assessed by serum neutralization assay (SNA) and ELISA, respectively. Results: Presence of Ad-36 antibody was detected in 9 (12.69%) of 71 patients, 1 (1.44%) of 69 healthy control case by SNA and was statistically significant (p<0.05). Although serum LDL, total cholesterol, triglycerides, IL-6 and leptin levels were found significantly higher, adiponectin level was found paradoxically low in the obese group. While a significant difference haven't been detected for serum lipids and leptin, adiponectin levels were found significantly lower in adenovirus antibody positive cases of the obese group (p<0.05). Ad-36 have been determined as a risk factor with the value OR= 2.057 in the multivariate logistic regression analysis which not indicated a significant difference statistically between groups. Conclusion: These results demonstrated that Adv-36 presence might has a role in the relationship of children Ad36- obesity etiopathogenesis. Our adipokine results of obese children also support this relationship. However, we believe especially cohort- based studies with larger series are needed to provide clearer results for the relationship.
- Subjects
ADENOVIRUSES; LEPTIN; ADIPONECTIN; CHILDHOOD obesity; EPIDEMICS
- Publication
Turkish Journal of Immunology, 2016, Vol 4, p51
- ISSN
1301-109X
- Publication type
Article