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- Title
Longitudinal Magnetic Resonance Imaging Detects Onset and Progression of Chronic Rhinosinusitis from Infancy to School Age in Cystic Fibrosis.
- Authors
Wucherpfennig, Lena; Wuennemann, Felix; Eichinger, Monika; Schmitt, Niclas; Seitz, Angelika; Baumann, Ingo; Stahl, Mirjam; Graeber, Simon Y.; Jaehi Chung; Schenk, Jens-Peter; Alrajab, Abdulsattar; Kauczor, Hans-Ulrich; Mall, Marcus A.; Sommerburg, Olaf; Wielpütz, Mark O.
- Abstract
Rationale: Chronic rhinosinusitis (CRS) contributes to morbidity in patients with cystic fibrosis (CF). However, longitudinal data on CRS onset and progression is lacking. Objectives: To longitudinally evaluate CRS in CF from infancy to school age with paranasal sinus magnetic resonance imaging (MRI). Methods: A total of 64 children with CF (mean age at baseline, 1.161.6 yr; range, 0-5 yr) underwent a mean of 5.862.2 (range, 3-11 yr) subsequent annual MRI examinations. Additional 24 children (9.264.4 yr; range, 3-17 yr) homozygous for the F508del mutation underwent MRI before and at least 2 months after starting lumacaftor/ivacaftor. MRI was assessed using the previously evaluated CRS-MRI score. Results: In infancy, 65-87% of paranasal sinuses were opacified, and mucosal swelling was the dominant abnormality (58-97%). At preschool age (1-5 yr), 79-94% of sinuses were opacified (P,0.05 vs. infancy), and mucosal swelling was the most dominant abnormality (79-94%; P,0.05). At school age (at least 6 yr), almost all sinuses were opacified (71-99%; P,0.001-0.357 vs. preschool age), and mucopyoceles were the dominant abnormality in maxillary and frontal sinuses (53-56%; P,0.05-0.808). The CRS-MRI sum score increased from 22.469.6 in infancy to 34.269.6 in preschool age (P,0.001) and was 34.065.7 in school age (P = 0.052). In children under lumacaftor/ivacaftor therapy, the CRS-MRI sum score (20.563.3; P,0.05) and maxillary sinus subscore (20.561.5; P,0.05) improved. Conclusions: Longitudinal paranasal sinus MRI detects an early onset and progression of the severity of CRS from infancy to school age, and response to lumacaftor/ivacaftor therapy in children with CF. Our data support its role in the comprehensive noninvasive monitoring of CRS in children with CF. Clinical trial registered with www.clinicaltrials.gov (NCT 02270476).
- Publication
Annals of the American Thoracic Society, 2023, Vol 20, Issue 5, p687
- ISSN
2329-6933
- Publication type
Article
- DOI
10.1513/AnnalsATS.202209-763OC