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- Title
The genome anatomy of Corynebacterium pseudotuberculosis VD57 a highly virulent strain causing Caseous lymphadenitis.
- Authors
Almeida, Sintia; Tiwari, Sandeep; Mariano, Diego; Souza, Flávia; Jamal, Syed Babar; Coimbra, Nilson; Raittz, Roberto Tadeu; Dorella, Fernanda Alves; de Carvalho, Alex Fiorine; Pereira, Felipe Luiz; de Castro Soares, Siomar; Leal, Carlos Augusto Gomes; Barh, Debmalya; Ghosh, Preetam; Figueiredo, Henrique; Moura-Costa, Lília Ferreira; Portela, Ricardo Wagner; Meyer, Roberto; Silva, Artur; Azevedo, Vasco
- Abstract
Corynebacterium pseudotuberculosis strain VD57 (Cp_VD57), a highly virulent, nonmotile, non-sporulating, and a mesophilic bacterium, was isolated from a goat's granulomatous lesion in the municipality of Juazeiro, Bahia State, Brazil. Here, we describe a set of features of the strain, together with the details of its complete genome sequence and annotation. The genome comprises of a 2.5 Mbp long, single circular genome with 2,101 protein-coding genes, 12 rRNA, 49 tRNA and 47 pseudogenes and a G + C content of 52.85%. Genetic variation was detected in Cp_VD57 using C. pseudotuberculosis strain 1002 as reference, wherein small genomic insertions and deletions were identified. The comparative analysis of the genome sequence provides means to better understand the host pathogen interactions of this strain and can also help us to understand the molecular and genetic basis of virulence of this bacterium.
- Subjects
CORYNEBACTERIUM pseudotuberculosis; PSEUDOTUBERCULOSIS; MICROBIAL virulence genetics; NUCLEOTIDE sequencing; COMPARATIVE studies; BACTERIAL variation
- Publication
Standards in Genomic Sciences, 2016, Vol 11, p1
- ISSN
1944-3277
- Publication type
Article
- DOI
10.1186/s40793-016-0149-7