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- Title
Effects of food intake on pharmacokinetics of mosapride in beagle dogs.
- Authors
Chae, J.‐W.; Song, B.‐J.; Baek, I.‐H.; Yun, H.‐Y.; Ma, J. Y.; Kwon, K.‐I.
- Abstract
This study was performed to determine the pharmacokinetic profile of mosapride in fasting and fed states. A single 5-mg oral dose of mosapride was administered to fasted ( n = 15) and fed ( n = 12) beagle dogs, and the plasma concentrations of mosapride were measured by liquid chromatography-tandem mass spectrometry. The resultant data were analyzed by noncompartmental analysis ( NCA). Mosapride was absorbed in fasted and fed dogs with similar Tmax. Both Cmax and AUC were significantly higher in the fasting group than in fed dogs, being four times (10.51 μg/ mL vs. 2.76 μg/ mL) and 3.5 times higher (38.53 h·μg/ mL vs. 10.22 h·μg/ mL), respectively. These findings suggest that food intake affects the pharmacokinetics of mosapride and that the dosage regimen for this drug need to be reconsidered.
- Subjects
PHARMACOKINETICS; LABORATORY dogs; INGESTION; FOOD substitutes; CHEMICAL kinetics
- Publication
Journal of Veterinary Pharmacology & Therapeutics, 2015, Vol 38, Issue 5, p497
- ISSN
0140-7783
- Publication type
Article
- DOI
10.1111/jvp.12200