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- Title
SARS-CoV-2 Seroprevalence in a Rural and Urban Household Cohort during First and Second Waves of Infections, South Africa, July 2020-March 2021.
- Authors
Kleynhans, Jackie; Tempia, Stefano; Wolter, Nicole; von Gottberg, Anne; Bhiman, Jinal N.; Buys, Amelia; Moyes, Jocelyn; McMorrow, Meredith L.; Kahn, Kathleen; Gómez-Olivé, F. Xavier; Tollman, Stephen; Martinson, Neil A.; Wafawanaka, Floidy; Lebina, Limakatso; du Toit, Jacques; Jassat, Waasila; Neti, Mzimasi; Brauer, Marieke; Cohen, Cheryl; PHIRST-C Group
- Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections may be underestimated because of limited access to testing. We measured SARS-CoV-2 seroprevalence in South Africa every 2 months during July 2020-March 2021 in randomly selected household cohorts in 2 communities. We compared seroprevalence to reported laboratory-confirmed infections, hospitalizations, and deaths to calculate infection-case, infection-hospitalization, and infection-fatality ratios in 2 waves of infection. Post-second wave seroprevalence ranged from 18% in the rural community children <5 years of age, to 59% in urban community adults 35-59 years of age. The second wave saw a shift in age distribution of case-patients in the urban community (from persons 35-59 years of age to persons at the extremes of age), higher attack rates in the rural community, and a higher infection-fatality ratio in the urban community. Approximately 95% of SARS-CoV-2 infections were not reported to national surveillance.
- Subjects
SOUTH Africa; SARS-CoV-2; COVID-19; AGE distribution; OLDER people; SEROPREVALENCE
- Publication
Emerging Infectious Diseases, 2021, Vol 27, Issue 12, p3020
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2712.211465