We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Seronegative neuromyelitis optica spectrum disorder patients diagnosed using new diagnostic criteria.
- Authors
Uzawa, Akiyuki; Mori, Masahiro; Uchida, Tomohiko; Masuda, Hiroki; Ohtani, Ryohei; Kuwabara, Satoshi
- Abstract
Background: Recently, new diagnostic criteria for neuromyelitis optica spectrum disorders (NMOSD) were published. Objective: Our primary aim was to evaluate the usefulness of the new diagnostic criteria in anti-aquaporin 4 (AQP4) antibody-negative cases. Methods: Consecutive 471 patients whose anti-AQP4 antibody was measured at Chiba University were reviewed. Results: Four anti-AQP4 antibody negative-patients, who fulfilled the new diagnostic criteria for NMOSD but not 2006 diagnostic criteria for neuromyelitis optica (NMO), were identified. They showed high cerebrospinal fluid interleukin-6 and glial fibrillary acidic protein levels, an absence of oligoclonal bands and/or cloud-like enhancement on magnetic resonance imaging, which are compatible findings for NMO. Conclusion: The new diagnostic criteria are clinically useful in seronegative NMOSD.
- Subjects
NEUROMYELITIS optica; AQUAPORINS; CEREBROSPINAL fluid; GLIAL fibrillary acidic protein; INTERLEUKIN-6; IMMUNOGLOBULINS; BRAIN imaging; DIAGNOSIS
- Publication
Multiple Sclerosis Journal, 2016, Vol 22, Issue 10, p1371
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458515615954