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- Title
Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population.
- Authors
Koichi Matsuda; Atsushi Takahashi; Middlebrooks, Candace D.; Wataru Obara; Yasutomo Nasu; Keiji Inoue; Kenji Tamura; Ichiro Yamasaki; Yoshio Naya; Chizu Tanikawa; Ri Cui; Figueroa, Jonine D.; Silverman, Debra T.; Rothman, Nathaniel; Mikio Namiki; Yoshihiko Tomita; Hiroyuki Nishiyama; Kenjiro Kohri; Takashi Deguchi; Masayuki Nakagawa
- Abstract
Throughgenome-wideassociationanalysisandanindependent replicationstudyusingatotal of1131bladdercancer cases and 12 558 non-cancer controls of Japanese populations,we identified a susceptibility locus on chromosome 15q24. SNP rs11543198 was associated with bladder cancer risk with odds ratio (OR) of 1.41 and P-value of 4.03 × 10–9. Subgroup analysis revealed rs11543198 to have a stronger effect in male smokers with OR of 1.66. SNP rs8041357, which is in complete linkage disequilibrium (r2 = 1) with rs11543198, was also associated with bladder cancer risk in Europeans (P = 0.045 for an additive and P = 0.025 for a recessive model), despite much lower minor allele frequency in Europeans (3.7%) compared with the Japanese (22.2%). Imputational analysis in this region suggested CYP1A2, which metabolizes tobacco-derived carcinogen, as a causative candidate gene. We also confirmedthe associationof previously reported loci,namelySLC14A1,APOBEC3A,PSCAandMYC,withbladder cancer. Our finding implies the crucial roles of genetic variations on the chemically associated development of bladder cancer.
- Publication
Human Molecular Genetics, 2015, Vol 24, Issue 4, p1177
- ISSN
0964-6906
- Publication type
Article
- DOI
10.1093/hmg/ddu512