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- Title
Copeptin: a potential blood biomarker for acute ischemic stroke.
- Authors
Oraby, Mohammed I.; Soliman, Rasha H.; Abd Elkareem, Rehab M.; Mohammed, Amna I.
- Abstract
Background: Copeptin is a new blood biomarker for acute ischemic stroke which emerged to assist clinicians with decision-making. Serum copeptin can accurately reflect vasopressin concentration, which plays a role in aggravation of inflammatory responses, ions and neurotransmitters dysfunctions. The objective of this work was to investigate the relation between copeptin level as a blood biomarker and the short-term prognosis of acute ischemic stroke after 3 months. The current study included 45 patients with first ever acute ischemic stroke and 45 healthy volunteers as a control. Clinical evaluation, CT and MRI of the brain, NIHSS on admission, and mRS after 3 months were done for the patients, and all the patients and control were subjected to assessment of serum level of copeptin by ELISA technique. Results: Copeptin level was significantly higher in patients with acute ischemic stroke compared to healthy control subjects (p-value = 0.001). Also, copeptin level was significantly higher in patients with severe stroke (NIHSS > 16) than in those with mild-to-moderate stroke (NIHSS 0–15) at presentation and in patients with unfavorable outcome (mRS 3–6) when compared to patients with favorable outcome (mRS 0–2) (p-value = 0.003 and 0.001, respectively). Copeptin level was significantly lower in patients who received thrombolytic therapy with rTPA (p-value = 0.049). Conclusion: Copeptin has an interesting potential as a new prognostic biomarker for patients with acute ischemic stroke as its level was significantly higher in patients with severe stroke and in patients with unfavorable outcome.
- Subjects
ISCHEMIC stroke; STROKE; BIOMARKERS; STROKE patients; TREATMENT effectiveness; MEDICAL personnel
- Publication
Egyptian Journal of Neurology, Psychiatry & Neurosurgery, 2021, Vol 57, Issue 1, p1
- ISSN
1110-1083
- Publication type
Article
- DOI
10.1186/s41983-021-00393-2