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- Title
Validating the Communication and Symbolic Behavior Scales–Developmental Profile Infant–Toddler Checklist (CSBS–DP ITC) Beyond Infancy in the CDKL5 Deficiency Disorder.
- Authors
Saldaris, Jacinta; Leonard, Helen; Wong, Kingsley; Jacoby, Peter; Spence, Mary; Marsh, Eric D.; Benke, Tim A.; Demarest, Scott; Downs, Jenny
- Abstract
CDKL5 deficiency disorder (CDD) results in early-onset epilepsy and lifelong cognitive and motor impairments. With no validated measure for communication in CDD, this study evaluated the psychometric properties of the Communication and Symbolic Behavior Scales-Developmental Profile Infant Toddler Checklist (CSBS–DP ITC). Caregivers (n = 150; affected individuals aged 1–29 years) completed the CSBS-DP ITC. Distribution of scores indicated a floor effect. There was poor divergent validity for the three-factor model but goodness of fit and convergent validity data were satisfactory for the one-factor model. Individuals with poorer overall functional abilities scored lower on the CSBS-DP ITC. Test–retest reliability was excellent. The floor effect could explain the very high reliability, suggesting problems as a sensitive outcome measure in clinical trials for CDD.
- Subjects
GOODNESS-of-fit tests; COMMUNICATIVE competence; RESEARCH funding; RESEARCH methodology evaluation; RESEARCH evaluation; FUNCTIONAL assessment; INFANTILE spasms; DEVELOPMENTAL disabilities; CAREGIVERS; COMMUNICATIVE disorders; COMMUNICATION; PSYCHOMETRICS; EPILEPSY; RESEARCH methodology; STATISTICAL reliability; FACTOR analysis
- Publication
Journal of Autism & Developmental Disorders, 2024, Vol 54, Issue 7, p2526
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-023-06002-w