We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
An Investigation of Age-related Neuropathophysiology in Autism Spectrum Disorder Using Fixel-based Analysis of Corpus Callosum White Matter Micro- and Macrostructure.
- Authors
Kirkovski, Melissa; Singh, Mervyn; Dhollander, Thijs; Fuelscher, Ian; Hyde, Christian; Albein-Urios, Natalia; Donaldson, Peter H; Enticott, Peter G
- Abstract
Fixel-based analysis was used to probe age-related changes in white matter micro- and macrostructure of the corpus callosum between participants with (N = 54) and without (N = 50) autism spectrum disorder (ASD). Data were obtained from the Autism Brain Imaging Data Exchange-II (ABIDE-II). Compared to age-matched controls, young adolescents with ASD (11.19 ± 7.54 years) showed reduced macroscopic fiber cross-section (logFC) and combined fiber-density and cross-section (FDC). Reduced fiber-density (FD) and FDC was noted in a marginally older (13.87 ± 3.15 years) ASD cohort. Among the oldest ASD cohort (17.07 ± 3.56 years), a non-significant trend indicative of reduced FD was noted. White matter aberration appears greatest and most widespread among younger ASD cohorts. This supports the suggestion that some early neuropathophysiological indicators in ASD may dissipate with age.
- Subjects
TELENCEPHALON; AUTISM; AGE distribution; MAGNETIC resonance imaging; LONGITUDINAL method; WHITE matter (Nerve tissue); COMPARATIVE studies
- Publication
Journal of Autism & Developmental Disorders, 2024, Vol 54, Issue 6, p2198
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-023-05980-1