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- Title
Improving the Diagnosis of Autism Spectrum Disorder in Fragile X Syndrome by Adapting the Social Communication Questionnaire and the Social Responsiveness Scale-2.
- Authors
Kidd, Sharon A.; Berry-Kravis, Elizabeth; Choo, Tse Hwei; Chen, Chen; Esler, Amy; Hoffmann, Anne; Andrews, Howard F.; Kaufmann, Walter E.
- Abstract
We carried out a psychometric assessment of the Social Communication Questionnaire (SCQ) and the Social Responsiveness Scale (SRS-2) in fragile X syndrome (FXS), relative to clinician DSM5-based diagnosis of autism spectrum disorder (ASD) in FXS. This was followed by instrument revisions that included: removal of non-discriminating and/or low face validity items for FXS; use of receiver operating characteristic (ROC) curves to determine optimal cut points for the original and revised measures; an exploratory factor analysis to outline subscales better representing ASD in FXS; and creation of a "triple criteria" diagnosis to better delineate ASD subgroups in FXS. These methods improved the sensitivity and/or specificity of the SCQ and SRS-2, but diagnostic accuracy of ASD remains problematic in FXS.
- Subjects
DIAGNOSIS of autism; TEST validity; FACTOR analysis; FRAGILE X syndrome; RESEARCH methodology; CLASSIFICATION of mental disorders; PSYCHOMETRICS; QUALITY assurance; QUESTIONNAIRES; RESEARCH; RECEIVER operating characteristic curves; RESEARCH methodology evaluation
- Publication
Journal of Autism & Developmental Disorders, 2020, Vol 50, Issue 9, p3276
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-019-04148-0