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- Title
Brief Report: Maternal Opioid Prescription from Preconception Through Pregnancy and the Odds of Autism Spectrum Disorder and Autism Features in Children.
- Authors
Rubenstein, Eric; Young, Jessica C.; Croen, Lisa A.; DiGuiseppi, Carolyn; Dowling, Nicole F.; Lee, Li-Ching; Schieve, Laura; Wiggins, Lisa D.; Daniels, Julie
- Abstract
Opioid use during pregnancy is associated with suboptimal pregnancy outcomes. Little is known about child neurodevelopmental outcomes. We examined associations between maternal opioid prescriptions preconception to delivery (peri-pregnancy) and child's risk of ASD, developmental delay/disorder (DD) with no ASD features, or ASD/DD with autism features in the Study to Explore Early Development, a case-control study of neurodevelopment. Preconception opioid prescription was associated with 2.43 times the odds of ASD [95% confidence interval (CI) 0.99, 6.02] and 2.64 times the odds of ASD/DD with autism features (95% CI 1.10, 6.31) compared to mothers without prescriptions. Odds for ASD and ASD/DD were non-significantly elevated for first trimester prescriptions. Work exploring mechanisms and timing between peri-pregnancy opioid use and child neurodevelopment is needed.
- Subjects
AUTISM risk factors; DEVELOPMENTAL disabilities; CHILD health services; CONFIDENCE intervals; DRUG utilization; MEDICAL prescriptions; NARCOTICS; FIRST trimester of pregnancy; SYMPTOMS; CASE-control method; PRENATAL exposure delayed effects; ODDS ratio; DISABILITIES
- Publication
Journal of Autism & Developmental Disorders, 2019, Vol 49, Issue 1, p376
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-018-3721-8