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- Title
Evidence of Crohn's disease-related anti-glycoprotein 2 antibodies in patients with celiac disease.
- Authors
Roggenbuck, Dirk; Vermeire, Severine; Hoffman, Ilse; Reinhold, Dirk; Schierack, Peter; Goihl, Alexander; von Arnim, Ulrike; De Hertogh, Gert; Polymeros, Dimitrios; Bogdanos, Dimitrios P.; Bossuyt, Xavier
- Abstract
Background: Autoantibodies to exocrine-pancreatic glycoprotein 2 (anti-GP2) are Crohn's disease (CD) markers. However, CD-specific antibodies have also been found in celiac-disease (CeD) patients, in which type 1 diabetes-specific autoantibodies against endocrine pancreatic targets can be present. We investigated whether anti-GP2 are also present in CeD, a disease like CD which is also characterised by intestinal mucosal inflammation with barrier impairment. Methods: Antibodies against GP2, tissue transglutaminase (tTG), deamidated gliadin (dGD), glutamic decarboxylase (GAD), and islet antigen-2 (IA2) were tested in sera from 73 CD patients, 90 blood donors (BD), and 79 (58 de novo) CeD patients (2 consecutive sera were available from 40 patients). Results: IgA and/or IgG anti-GP2 were found in 15/79 (19.0%) CeD patients on at least one occasion, in 25/73 (34.2%) CD patients, and in 4/90 (4.4%) BD (CeD vs. CD, p = 0.042; BD vs. CeD and CD, p < 0.001, respectively). Amongst the 58 de novo CeD patients, anti-GP2 IgA and/or IgG were present in 11 (19.0%). Anti-GP2 IgA was significantly less prevalent in CeD compared with CD (p = 0.004). Anti-GP2 IgA and IgG in CD patients demonstrated a significantly higher median level compared to patients with CeD (p < 0.001, p = 0.008, respectively). IgA anti-GP2 levels correlated significantly with IgA anti-tTG and anti-dGD levels in CeD Spearman's coefficient of rank correlation (ρ) = 0.42, confidence interval (CI): 0.26-0.56, p < 0.001; ρ = 0.54, CI 0.39-0.65, p < 0.001, respectively. Conclusions: The presence of anti-GP2 in CeD patients supports the notion that loss of tolerance to GP2 can probably be a manifestation of an autoinflammatory process in this intestinal disorder.
- Publication
Clinical Chemistry & Laboratory Medicine, 2015, Vol 53, Issue 9, p1349
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm-2014-0238