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- Title
Pre-surgical Prediction of Ischemic Mitral Regurgitation Recurrence Using In Vivo Mitral Valve Leaflet Strains.
- Authors
Narang, Harshita; Rego, Bruno V.; Khalighi, Amir H.; Aly, Ahmed; Pouch, Alison M.; Gorman, Robert C.; Gorman III, Joseph H.; Sacks, Michael S.
- Abstract
Ischemic mitral regurgitation (IMR) is a prevalent cardiac disease associated with substantial morbidity and mortality. Contemporary surgical treatments continue to have limited long-term success, in part due to the complex and multi-factorial nature of IMR. There is thus a need to better understand IMR etiology to guide optimal patient specific treatments. Herein, we applied our finite element-based shape-matching technique to non-invasively estimate peak systolic leaflet strains in human mitral valves (MVs) from in-vivo 3D echocardiographic images taken immediately prior to and post-annuloplasty repair. From a total of 21 MVs, we found statistically significant differences in pre-surgical MV size, shape, and deformation patterns between the with and without IMR recurrence patient groups at 6 months post-surgery. Recurrent MVs had significantly less compressive circumferential strains in the anterior commissure region compared to the recurrent MVs (p = 0.0223) and were significantly larger. A logistic regression analysis revealed that average pre-surgical circumferential leaflet strain in the Carpentier A1 region independently predicted 6-month recurrence of IMR (optimal cutoff value − 18%, p = 0.0362). Collectively, these results suggest greater disease progression in the recurrent group and underscore the highly patient-specific nature of IMR. Importantly, the ability to identify such factors pre-surgically could be used to guide optimal treatment methods to reduce post-surgical IMR recurrence.
- Subjects
MITRAL valve insufficiency; MITRAL valve; REFERENCE values; LOGISTIC regression analysis; PAMPHLETS; DISEASE relapse
- Publication
Annals of Biomedical Engineering, 2021, Vol 49, Issue 12, p3711
- ISSN
0090-6964
- Publication type
Article
- DOI
10.1007/s10439-021-02772-5