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- Title
Assembly/Disassembly of DNA-Au Nanoparticles: A Strategy of Intervention.
- Authors
I-Im S. Lim; Lingyan Wang; Chandrachud, Uma; Susannah Gal; Chuan-Jian Zhong
- Abstract
This report describes the viability of a strategy for manipulating the assembly/disassembly processes of DNA-Au nanoparticles by molecular intervention. Using the temperature-induced assembly and disassembly processes of DNAs and gold nanoparticles as a model system, the introduction of a molecular recognition probe is demonstrated to lead to the intervention of the assembly/ disassembly processes depending on its specific biorecognition. This process can be detected by monitoring the change in the optical properties of gold nanoparticles and their DNA assemblies. Implications of the preliminary results to exploration of the resulting nanostructures for fine-tuning of the interfacial reactivities in DNA-based bioassays and biomaterial engineering are also discussed.
- Subjects
DEOXYRIBOSE; NANOSTRUCTURED materials; BIOMEDICAL materials; ORGANOGOLD compounds; LIGAND binding (Biochemistry); MOLECULAR biology; PHYSIOLOGICAL optics; BIOPHYSICS; BIOLOGICAL assay
- Publication
Research Letters in Nanotechnology, 2008, p1
- ISSN
1687-6849
- Publication type
Article
- DOI
10.1155/2008/527294