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- Title
p53 protein in aggressive and non-aggressive basal cell carcinoma.
- Authors
De Rosa, G.; Staibano, S.; Barra, E.; Donofrio, V.; Salvarotre, G.; Vessecchia, G.; Boscaino, A.
- Abstract
Basal cell carcinoma (BCC) is the most frequent cutaneous neoplasm, with a generally favorable clinical behavior. Sometimes, indeed, it recurs after therapy and/or metastasizes. As point mutations in the coding sequence of the p53 tumor suppressor gene have been implicated in the progression of may human tumors, we studied the expression of p53 protein on this neoplasia. We tested immunohistochemically the positivity for p53 protein (NCL-p53-CM1, YLEM) on 19 case of morphologically "non aggressive" BCC (BCC1) and on 19 "aggressive" BCC (BCC2), all with one or more relapses and 3 with distant metastases also. Results were related to clinico-pathological and follow-up data. All but one BCC2 were found positive for p53 protein. Conversely, only 2 cases of BCC1 exhibited low immunoreactivity for p53 protein, with high statistical differences between the two groups. No correlation was found between the immunoreactivity , age of patients, and site of the lesions. The availability of immunohistochemistry and the relatively easy interpretation of the results make screening for p53 protein a possibly useful tool in the prognostic evaluation of BCC.
- Subjects
BASAL cell carcinoma; TUMORS; TUMOR suppressor genes; METASTASIS; SKIN cancer; CANCER genetics
- Publication
Journal of Cutaneous Pathology, 1993, Vol 20, Issue 5, p429
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/j.1600-0560.1993.tb00666.x