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- Title
Association of proinflammatory cytokine IL-20 gene polymorphism with psoriasis in north Indian population.
- Authors
Wani, Aadil; Ganai, Bashir Ahmad; Akhtar, Tahseena; Narang, Tarun; Kaur, Rajinder
- Abstract
Background: IL-20 plays an important role in the inflammatory and hyperproliferative dermatosis of psoriasis. Aim: The aim of the study was to determine whether the IL-20 gene polymorphism, haplotype and serum level confer pathogenesis of psoriasis. Subjects and methods: 200 psoriatic patients and 200 controls were genotyped for four IL-20 polymorphic sites by polymerase chain reaction. Serum levels of IL-20 were measured by ELISA. Results: Our results demonstrated that polymorphism of IL-120 -1380 A/G (adjusted* OR 5.52; (95% CI = 2.43-12.55) was found to be in association with increased risk of psoriasis while as IL-20-1462 G/A (adjusted* OR = 0.11 95; (95% CI = 0.03-0.34) was found to be in association with decreased risk of psoriasis and IL-20-1053 G/T adjusted* OR 1.99; (95% CI = 0.86-4.64), IL-20-3978 T/C(adjusted* OR = 12.87; (95% CI = 0.97-79.54) polymorphism does not show any significant association with the risk of psoriasis. HT4 TG haplotype is associated with decreased risk of psoriasis. Serum IL-20 level significantly increases in patients, as compared to controls with non-significant correlation between serum IL-20 and psoriasis severity. Conclusion: These findings suggest that IL-20 polymorphism have significant role towards the susceptibility of psoriasis in north Indian population. Evaluating the role of IL-20 cytokine in pathogenesis of psoriasis will prove helpful for the development of psoriasis management.
- Subjects
INTERLEUKINS; GENETIC polymorphisms; PSORIASIS &; genetics; POLYMERASE chain reaction; HAPLOTYPES
- Publication
Egyptian Journal of Medical Human Genetics, 2018, Vol 19, Issue 3, p201
- ISSN
1110-8630
- Publication type
Article
- DOI
10.1016/j.ejmhg.2017.09.002