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- Title
Susceptibility genes for schizophrenia.
- Authors
HASHIMOTO, RYOTA; HATTORI, SATOKO; CHIBA, SACHIE; YAGASAKI, YUKI; OKADA, TAKEYA; KUMAMARU, EMI; MORI, TAKEYUKI; NEMOTO, KIYOTAKA; TANII, HISASHI; HORI, HIROAKI; NOGUCHI, HIROKO; NUMAKAWA, TADAHIRO; OHNISHI, TAKASHI; KUNUGI, HIROSHI
- Abstract
It is well known that genetic factors contribute to the susceptibility for schizophrenia. Recent advances in the molecular genetics of schizophrenia strongly suggest several susceptibility genes (e.g. dysbindin, neuregulin-1, DISC1, COMT, G72, RGS4 and Akt1). We discuss the evidence and biology of these genes. As glutamate transmission is especially implicated in these genes, neurobiological basis of schizophrenia might be elucidated by investigation of functional interactions between susceptibility genes for schizophrenia and the glutamatergic system.
- Subjects
GENETICS of schizophrenia; MEDICAL genetics; GENETIC disorders; MOLECULAR genetics; GLUTAMIC acid
- Publication
Psychiatry & Clinical Neurosciences, 2006, Vol 60, pS4
- ISSN
1323-1316
- Publication type
Article
- DOI
10.1111/j.1440-1819.2006.01522.x-i1