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- Title
Ethanol Extract of Elaeocarpus petiolatus Inhibits Lipopolysaccharide-Induced Inflammation in Macrophage Cells.
- Authors
Kwon, Ok-Kyoung; Ahn, Kyung-Seop; Park, Ji-Won; Jang, Ha-Young; Joung, Hyouk; Lee, Hyeong-Kyu; Oh, Sei-Ryang
- Abstract
Elaeocarpus petiolatus is known to exert active oxygen scavenging, anti-aging, and whitening actions. However, the biological effects of E. petiolatus on inflammation and the underlying mechanisms are yet to be established. In the present study, we investigated the anti-inflammatory effects of the ethanol extract from E. petiolatus (EPE) bark in murine Raw264.7 macrophages stimulated with lipopolysaccharide (LPS). EPE inhibited the production of PGE, TNF-α, and IL-1β in a dose-dependent manner in Raw264.7 cells stimulated with LPS. The decrease in PGE production was correlated with reduced COX-2 expression. Furthermore, EPE suppressed the phosphorylation of extracellular signal-related kinases (ERK), c-Jun N-terminal kinase (JNK), and p38 as well as translocation of the NF-κB p65 subunit from the cytosol to nucleus. Our results suggest that EPE exerts anti-inflammatory activity through inhibition of inflammatory mediators, such as PGE, TNF-α, and IL-1β, and downregulation of COX-2 via suppression of NF-κB translocation and phosphorylation of ERK, JNK, and p38 in LPS-stimulated Raw264.7 cells.
- Subjects
ELAEOCARPUS; PLANT extracts; LIPOPOLYSACCHARIDES; INFLAMMATION; MACROPHAGES; PHOSPHORYLATION; CYTOSOL
- Publication
Inflammation, 2012, Vol 35, Issue 2, p535
- ISSN
0360-3997
- Publication type
Article
- DOI
10.1007/s10753-011-9343-3