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- Title
Synthesis and Biological Activity of Oxazolopyrimidines.
- Authors
De Coen, Laurens M.; Roman, Bart I.; Movsisyan, Marine; Heugebaert, Thomas S. A.; Stevens, Christian V.
- Abstract
In this work, the synthesis of oxazolo[4,5‐d]pyrimidines and oxazolo[5,4‐d]pyrimidines is reviewed. The review is focused on the construction of the scaffold rather than on its further modification. Nevertheless, selected examples illustrate some of the most common modifications of these scaffolds. The synthetic part is complemented by an overview of their biological activity. This review covers literature and patents from 1967 until the present.
- Subjects
PYRIMIDINE synthesis; BIOACTIVE compounds; RING formation (Chemistry); ANNULATION; BASE pairs
- Publication
European Journal of Organic Chemistry, 2018, Vol 2018, Issue 19, p2148
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201800133