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- Title
Exercise-Induced Oxygen Desaturation as a Predictive Factor for Longitudinal Decline in 6-Minute Walk Distance in Subjects With COPD.
- Authors
Shogo Misu; Masahiro Kaneko; Hideki Sakai; Yutaro Oki; Yukari Fujimoto; Akira Ishikawa; Rei Ono
- Abstract
BACKGROUND: There are limited longitudinal studies reporting predictive factors for decline in 6-min walk distance (6MWD) in patients with COPD. While previous studies have confirmed the association between air-flow limitation and decline in 6MWD, other factors have not been clarified. The objective of this study was to investigate whether exercise-induced oxygen desaturation (EID) could be a predictive factor for decline in 6MWD in patients with COPD. The interactive effect of air-flow limitation on the association between EID and decline in 6MWD was also investigated. METHODS: A longitudinal observational study was conducted with 71 out-patients with COPD who were followed for 1 year. 6MWD, EID, spirometry, and clinical characteristics were assessed. The effect of EID on changes in 6MWD was examined using linear regression analyses. Furthermore, the subjects were categorized into 4 groups according to their EID and air-flow limitation status, and changes in 6MWD were compared among the groups. RESULTS: 51 subjects completed the follow-up assessments, and 29 (56.9%) experienced EID. Multiple linear regression model revealed that EID was the only predictive factor for changes in 6MWD after adjusting for confounders (β = -38.9, P = .02). As results of multiple comparisons among the 4 groups based on EID and air-flow limitation status, changes in 6MWD in the EID and severe air-flow limitation group were the lowest. CONCLUSION: Our results revealed that EID was a predictive factor for decline in the functional capacity of subjects with COPD. The assessment of EID and air-flow limitation would thus be useful in estimating the prognosis of decline in the functional capacity of patients with COPD.
- Subjects
REACTIVE oxygen species; ANALYSIS of variance; CHI-squared test; EXERCISE; LIFE skills; LONGITUDINAL method; OBSTRUCTIVE lung diseases; SCIENTIFIC observation; OXIMETRY; OXYGEN in the body; SPIROMETRY; T-test (Statistics); PULSE oximeters; MULTIPLE regression analysis; CONTINUING education units; DATA analysis software; FUNCTIONAL assessment; DESCRIPTIVE statistics; LUNG volume measurements
- Publication
Respiratory Care, 2019, Vol 64, Issue 2, p142
- ISSN
0020-1324
- Publication type
Article
- DOI
10.4187/respcare.06169