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- Title
Incomplete Modeling of the Effect of Antiretroviral Therapy on the Risk of Cardiovascular Events.
- Authors
Young, Jim; Moodie, Erica E. M.; Abrahamowicz, Michal; Klein, Marina B.; Weber, Rainer; Bucher, Heiner C.
- Abstract
The article focuses on cardiovascular disease (CVD) caused by a single antiretroviral drug or combination of drugs. Topics discussed include flexible cumulative exposure modelling for the treatment of CVD, sensitivity analysis using different variables, and use of cell count and viral load in drug combinations. Also it mentions different variables such as dyslipidaemia and lipodystrophy that control the exposure of abacavir.
- Subjects
CARDIOVASCULAR diseases; ANTIRETROVIRAL agents; COMBINATION drug therapy; CUMULATIVE distribution function; LIPODYSTROPHY; ABACAVIR
- Publication
Clinical Infectious Diseases, 2015, Vol 61, Issue 7, p1206
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/civ515