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- Title
Polymorphism of the β<sub>3</sub>-adrenergic-receptor gene associated with maternal body weight gain and fetal body weight.
- Authors
Arakawa, M; Kurabayashi, T; Tomita, M; Yahata, T; Takakuwa, K; Tanaka, K
- Abstract
Objective: To investigate whether the polymorphism of the β3-adrenergic-receptor (β3-AR) gene was associated with the maternal and fetal conditions during pregnancy. Method: The association between the genotypes of β3-AR and clinical phenotypes during pregnancy was analyzed in 92 women (a total of 126 pregnancies). Result: The overall frequency of the Trp64Arg β3-AR allele in 92 pregnant Japanese women was 20.7%. In 125 pregnancies, excluding one homozygote (51 heterozygote group and 74 wild-type group), a significant difference in the maternal body weight gain during pregnancy was observed between the heterozygote group and wild-type group. The heterozygote group had significantly higher neonatal body weights, neonatal body weight index values and placental weights compared with the wild-type group. Conclusion: The Trp64Arg heterozygous mutation in the β3-AR gene is associated with not only the increase in the body weight of pregnant Japanese women but also the increase in the weights of their neonate and placentas.
- Publication
International Journal of Gynecology & Obstetrics, 1998, Vol 62, Issue 3, p243
- ISSN
0020-7292
- Publication type
Article
- DOI
10.1016/S0020-7292(98)00112-X