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- Title
Preparation of Cu<sub>2</sub>O-Reduced Graphene Nanocomposite Modified Electrodes towards Ultrasensitive Dopamine Detection.
- Authors
He, Quanguo; Liu, Jun; Liu, Xiaopeng; Li, Guangli; Deng, Peihong; Liang, Jing
- Abstract
Cu2O-reduced graphene oxide nanocomposite (Cu2O-RGO) was used to modify glassy carbon electrodes (GCE), and applied for the determination of dopamine (DA). The microstructure of Cu2O-RGO nanocomposite material was characterized by scanning electron microscope. Then the electrochemical reduction condition for preparing Cu2O-RGO/GCE and experimental conditions for determining DA were further optimized. The electrochemical behaviors of DA on the bare electrode, RGO- and Cu2O-RGO-modified electrodes were also investigated using cyclic voltammetry in phosphate-buffered saline solution (PBS, pH 3.5). The results show that the oxidation peaks of ascorbic acid (AA), dopamine (DA), and uric acid (UA) could be well separated and the peak-to-peak separations are 204 mV (AA-DA) and 144 mV (DA-UA), respectively. Moreover, the linear response ranges for the determination of 1 × 10-8 mol/L~1 × 10-6 mol/L and 1 × 10-6 mol/L~8 × 10-5 mol/L with the detection limit 6.0 × 10-9 mol/L (S/N = 3). The proposed Cu2O-RGO/GCE was further applied to the determination of DA in dopamine hydrochloride injections with satisfactory results.
- Subjects
COPPER oxide; GRAPHENE oxide; NANOCOMPOSITE materials; CARBON electrodes; SCANNING electron microscopes; ELECTROCHEMICAL sensors; DOPAMINE
- Publication
Sensors (14248220), 2018, Vol 18, Issue 1, p199
- ISSN
1424-8220
- Publication type
Article
- DOI
10.3390/s18010199