We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
215-LB: Diabetes and Obesity Are the Main Drivers of Increasing Chronic Liver Disease in the United States (U.S.) in the Past Three Decades.
- Authors
YOUNOSSI, ZOBAIR M.; STEPANOVA, MARIA; YOUNOSSI, YOUSSEF; GOLABI, PEGAH; MISHRA, ALITA; RAFIQ, NILA
- Abstract
Background: Recently, the face of liver disease (LD) in the U.S. may be changing. The aim was to assess the prevalence of LDs in the U.S. over 3 decades. Methods: Clinical data from NHANES were used to establish the diagnoses of chronic hepatitis C (CHC), B (CHB) alcoholic LD (ALD), and nonalcoholic fatty LD (NAFLD). Results: 58,731 adults with LD were included. During the study, prevalence of CHB and ALD remained stable (0.3%-0.4% and 0.8%-1.0%, trend p>0.05); while the prevalence of CHC decreased nearly 2 fold [from 1.6% to 0.9% (p=0.03)]. In contrast, prevalence of NAFLD increased from 20.0% to 28.3% to 33.2% (p<0.0001). At the same time, increases were observed in the rates of obesity (22.2% to 31.0% to 38.9%) and type 2 diabetes (7.2% to 8.2% to 13.5% same years). Yearly trend analyses showed that the only liver disease with consistently increasing prevalence was NAFLD (Kendall tau=0.64, P=0.01). Multivariate regression analysis showed that after adjustment for age, gender, and ethnicity, obesity 10.4 (9.5-11.3), diabetes 3.7 (3.2-4.2), hypertension 2.3 (2.1-2.5) and hyperlipidemia 1.8 (1.6-2.1)) were the major independent predictors of NAFLD. Conclusions: Over the past 30 years in the U.S., NAFLD is the only liver disease with increasing prevalence. The increasing prevalence of NAFLD is primarily driven by diabetes and obesity. Disclosure: Z.M. Younossi: Consultant; Self; Gilead Sciences, Inc., Intercept Pharmaceuticals, Inc., Merck & Co., Inc., Novartis AG, Novo Nordisk A/S. Research Support; Self; Bristol-Myers Squibb Company. M. Stepanova: None. Y. Younossi: None. P. Golabi: None. A. Mishra: None. N. Rafiq: None.
- Publication
Diabetes, 2019, Vol 68, pN.PAG
- ISSN
0012-1797
- Publication type
Article
- DOI
10.2337/db19-215-LB