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- Title
Preparation and Activity of Hemostatic and Antibacterial Dressings with Greige Cotton/Zeolite Formularies Having Silver and Ascorbic Acid Finishes.
- Authors
Edwards, J. Vincent; Prevost, Nicolette T.; Hinchliffe, Doug J.; Nam, Sunghyun; Chang, SeChin; Hron, Rebecca J.; Madison, Crista A.; Smith, Jade N.; Poffenberger, Chelsie N.; Taylor, Michelle M.; Martin, Erika J.; Dixon, Kirsty J.
- Abstract
The need for prehospital hemostatic dressings that exert an antibacterial effect is of interest for prolonged field care. Here, we consider a series of antibacterial and zeolite formulary treatment approaches applied to a cotton-based dressing. The design of the fabric formulations was based on the hemostatic dressing TACGauze with zeolite Y incorporated as a procoagulant with calcium and pectin to facilitate fiber adherence utilizing silver nanoparticles, and cellulose-crosslinked ascorbic acid to confer antibacterial activity. Infra-red spectra were employed to characterize the chemical modifications on the dressings. Contact angle measurements were employed to document the surface hydrophobicity of the cotton fabric which plays a role in the contact activation of the coagulation cascade. Ammonium Y zeolite-treated dressings initiated fibrin equal to the accepted standard hemorrhage control dressing and showed similar improvement with antibacterial finishes. The antibacterial activity of cotton-based technology utilizing both citrate-linked ascorbate-cellulose conjugate analogs and silver nanoparticle-embedded cotton fibers was observed against Staphylococcus aureus and Klebsiella pneumoniae at a level of 99.99 percent in the AATCC 100 assay. The hydrogen peroxide levels of the ascorbic acid-based fabrics, measured over a time period from zero up to forty-eight hours, were in line with the antibacterial activities.
- Subjects
VITAMIN C; ANTIBACTERIAL agents; ZEOLITE Y; COTTON fibers; SILVER nanoparticles; ZEOLITES; PECTINS
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 23, p17115
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms242317115