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- Title
Preparation, Characterization and Evaluation of the Anti-Inflammatory Activity of Epichlorohydrin-β-Cyclodextrin/Curcumin Binary Systems Embedded in a Pluronic ® /Hyaluronate Hydrogel.
- Authors
Fernández-Romero, Ana-María; Maestrelli, Francesca; García-Gil, Sara; Talero, Elena; Mura, Paola; Rabasco, Antonio M.; González-Rodríguez, María Luisa
- Abstract
Curcumin (Cur) is an anti-inflammatory polyphenol that can be complexed with polymeric cyclodextrin (CD) to improve solubility and bioavailability. The aim of the present work was to prepare a CurCD hydrogel to treat inflammatory skin conditions. Epichlorohydrin-β-CD (EpiβCD) was used as polymeric CD. To characterize the binary system, solid-state and in-solution studies were performed. Afterwards, an experimental design was performed to optimize the hydrogel system. Finally, the CurEpiβCD hydrogel system was tested for anti-inflammatory activity using a HaCat psoriasis cell model. Co-grinded Cur/EpiβCD binary system showed a strong interaction and Curcumin solubility was much improved. Its combination with Pluronic® F-127/hyaluronate hydrogel demonstrated an improvement in release rate and Curcumin permeation. After testing its anti-inflammatory activity, the system showed a significant reduction in IL-6 levels. Hydrogel-containing CurEpiβCD complex is a great alternative to treat topical inflammatory diseases.
- Subjects
ANTI-inflammatory agents; CYCLODEXTRINS; CURCUMIN; SOLUBILITY
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 24, p13566
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms222413566