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- Title
Temporomandibular Joint Osteoarthritis: Regenerative Treatment by a Stem Cell Containing Advanced Therapy Medicinal Product (ATMP)—An In Vivo Animal Trial.
- Authors
Köhnke, Robert; Ahlers, Marcus Oliver; Birkelbach, Moritz Alexander; Ewald, Florian; Krueger, Michael; Fiedler, Imke; Busse, Björn; Heiland, Max; Vollkommer, Tobias; Gosau, Martin; Smeets, Ralf; Rutkowski, Rico
- Abstract
Temporomandibular joint osteoarthritis (TMJ-OA) is a chronic degenerative disease that is often characterized by progressive impairment of the temporomandibular functional unit. The aim of this randomized controlled animal trial was a comparative analysis regarding the chondroregenerative potency of intra-articular stem/stromal cell therapy. Four weeks after combined mechanical and biochemical osteoarthritis induction in 28 rabbits, therapy was initiated by a single intra-articular injection, randomized into the following groups: Group 1: AB Serum (ABS); Group 2: Hyaluronic acid (HA); Group 3: Mesenchymal stromal cells (STx.); Group 4: Mesenchymal stromal cells in hyaluronic acid (HA + STx.). After another 4 weeks, the animals were euthanized, followed by histological examination of the removed joints. The histological analysis showed a significant increase in cartilage thickness in the stromal cell treated groups (HA + STx. vs. ABS, p = 0.028; HA + ST.x vs. HA, p = 0.042; STx. vs. ABS, p = 0.036). Scanning electron microscopy detected a similar heterogeneity of mineralization and tissue porosity in the subchondral zone in all groups. The single intra-articular injection of a stem cell containing, GMP-compliant advanced therapy medicinal product for the treatment of iatrogen induced osteoarthritis of the temporomandibular joint shows a chondroregenerative effect.
- Subjects
TEMPOROMANDIBULAR joint; STEM cell treatment; REGENERATION (Biology); INTRA-articular injections; STROMAL cells
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 1, p443
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22010443