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- Title
Rutin-Enriched Extract from Coriandrum sativum L. Ameliorates Ionizing Radiation-Induced Hematopoietic Injury.
- Authors
Xiaodan Han; Xiaolei Xue; Yu Zhao; Yuan Li; Weili Liu; Junling Zhang; Saijun Fan
- Abstract
Hematopoietic injury is a major cause of mortality in radiation accidents and a primary side effect in patients undergoing radiotherapy. Ionizing radiation (IR)-induced myelosuppression is largely attributed to the injury of hematopoietic stem and progenitor cells (HSPCs). Coriander is a culinary herb with multiple pharmacological effects and has been widely used in traditional medicine. In this study, flavonoids were identified as the main component of coriander extract with rutin being the leading compound (rutin-enriched coriander extract; RE-CE). We evaluated the radioprotective effect of RE-CE against IR-induced HSPCs injury. Results showed that RE-CE treatment markedly improved survival, ameliorated organ injuries and myelosuppression, elevated HSPCs frequency, and promoted differentiation and proliferation of HSPCs in irradiated mice. The protective role of RE-CE in hematopoietic injury is probably attributed to its anti-apoptotic and anti-DNA damage effect in irradiated HSPCs. Moreover, these changes were associated with reduced reactive oxygen species (ROS) and enhanced antioxidant enzymatic activities in irradiated HSPCs. Collectively, these findings demonstrate that RE-CE is able to ameliorate IR-induced hematopoietic injury partly by reducing IR-induced oxidative stress.
- Subjects
RADIATION-protective agents; HEMATOPOIETIC system; BONE marrow; HEMATOPOIETIC stem cell transplantation; THERAPEUTIC use of plant extracts; CORIANDER; IONIZING radiation dosage; DNA damage; WOUNDS &; injuries; THERAPEUTICS
- Publication
International Journal of Molecular Sciences, 2017, Vol 18, Issue 5, p942
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms18050942