We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Nuclear Receptor Regulation of Aquaporin-2 in the Kidney.
- Authors
Xiao-Yan Zhang; Bing Wang; You-Fei Guan
- Abstract
Aquaporin-2 (AQP2) is a vasopressin-regulated water channel responsible for regulating water reabsorption through the apical plasma membrane of the principal cells of renal collecting ducts. It has been found that dysregulation and dysfunction of AQP2 cause many disorders related to water balance in people and animals, including polyuria and dilutional hyponatremia. Classically, AQP2 mRNA and protein expression and its membrane translocation are regulated by systemic vasopressin involving short-term regulation of AQP2 trafficking to and from the apical plasma membrane and long-term regulation of the total amount of the AQP2 protein in the cell. Recently, increasing evidence has demonstrated that collecting duct AQP2 expression and membrane translocation are also under the control of many other local factors, especially nuclear receptors. Here, we briefly review the progress of studies in this area and discuss the role of nuclear receptors in the regulation of water reabsorption via affecting AQP2 expression and function.
- Subjects
NUCLEAR receptors (Biochemistry); AQUAPORINS; VASOPRESSIN; MESSENGER RNA; HYPONATREMIA
- Publication
International Journal of Molecular Sciences, 2016, Vol 17, Issue 7, p1105
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms17071105