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- Title
Redefining Chronic Toxoplasmosis--A T Cell Exhaustion Perspective.
- Authors
Bhadra, Rajarshi; Khan, Imtiaz A.
- Abstract
The article discusses CD8 T cells exhaustion during chronic toxoplasmosis and its implication for immunotherapy against Toxoplasma gondii protozoa. Based on observation, HIV-infected nonprogressors is controlled by virus-specific polyfunctional CD8 T cell response and development of memory phenotype CD44 and CD127. A study is cited which explored the positive costimulatory signals CD40-CD40L pathway during the rescue of exhausted C8 T cells.
- Subjects
T cells; TOXOPLASMA gondii; TOXOPLASMOSIS; IMMUNOTHERAPY; PHENOTYPES
- Publication
PLoS Pathogens, 2012, Vol 8, Issue 10, p1
- ISSN
1553-7366
- Publication type
Article
- DOI
10.1371/journal.ppat.1002903