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- Title
Effect of Age and Acute Exercise on Circulating Angioregulatory Factors.
- Authors
Luttrell, Meredith J.; Mardis, Benjamin R.; Bock, Joshua M.; Iwamoto, Erika; Hanada, Satoshi; Ueda, Kenichi; Feider, Andrew J.; Temperly, Kenzie; Casey, Darren
- Abstract
The balance of angiogenic factors, including vascular endothelial growth factor (VEGF), and angiostatic factors, like thrombospondin-1 (TSP-1) and endostatin, controls striated muscle angiogenic responses to exercise training. The effect of age on circulating levels of these factors following a bout of exercise is unclear. The authors hypothesized that older adults would have lower circulating VEGF but higher TSP-1 and endostatin after exercise compared with young adults. Ten young and nine older participants cycled for 45 min at 60% estimated HRmax. Serum [VEGF], [TSP-1], and [endostatin] obtained before (PREX), immediately after (POSTX0), and 3 hr after (POSTX3) exercise were analyzed. [VEGF] increased in older adults only from PREX to POSTX0 (p <.05). [TSP-1] increased in both age groups (p <.05). There was no effect of age or exercise on [endostatin]. In conclusion, immediately after exercise, both groups had a similar increase in [TSP-1], but [VEGF] increased in older adults only.
- Subjects
MORPHOGENESIS; NEOVASCULARIZATION inhibitors; CARDIOVASCULAR system physiology; AGE distribution; AGING; EXERCISE; GLYCOPROTEINS; VASCULAR endothelial growth factors; OLD age
- Publication
Journal of Aging & Physical Activity, 2021, Vol 29, Issue 3, p423
- ISSN
1063-8652
- Publication type
Article
- DOI
10.1123/japa.2020-0024