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- Title
Evaluation of compatibility among artemether, pyrimethamine and sulphadoxine using analytical and isothermal calorimetry techniques.
- Authors
Gupta, Sushma; Chadha, Renu
- Abstract
The objective of the present study is to identify interactions and incompatibilities among antimalarial drugs in solid state and solution phase. The potential interactions can affect the chemical nature, the stability and bioavailability of drugs and, consequently, their therapeutic efficacy and safety. Herein, the incompatibility studies were performed on artemether: sulphadoxine/pyrimethamine and their physical and treated binary and ternary mixtures. DSC, FT-IR and PXRD outcomes showed no significant chemical changes in physical mixtures and treated samples with respect to their pure samples. In solid state, no changes in data output (exotherm) was observed during conducting tests in isothermal heat flow among binary and ternary mixtures. In solution phase, more exothermic value of excess energy by calorimetry indicated stronger interaction in ternary mixtures relative to binary mixtures. Current investigation unambiguously connoted that artemether was compatible with pyrimethamine or sulphadoxine in combinations, but their ternary mixtures are not safe if co-formulated.
- Subjects
ANTIMALARIALS; BIOAVAILABILITY; X-ray diffraction; FOURIER transform infrared spectroscopy; SOLID state chemistry
- Publication
Journal of Thermal Analysis & Calorimetry, 2015, Vol 120, Issue 1, p759
- ISSN
1388-6150
- Publication type
Article
- DOI
10.1007/s10973-014-4124-5