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- Title
Grinding of drugs with pharmaceutical excipients at cryogenic temperatures.
- Authors
Shakhtshneider, T. P.; Danède, F.; Capet, F.; Willart, J. F.; Descamps, M.; Paccou, L.; Surov, E. V.; Boldyreva, E. V.; Boldyrev, V. V.
- Abstract
The effect of cryogenic grinding on the indomethacin (IMC) and its mixtures with polyvinylpyrrolidone (PVP) was studied by powder X-ray diffraction and differential scanning calorimetry. Cryoground mixtures were shown to form glass solutions. PVP inhibits the crystallization of IMC from the amorphous state: the crystallization temperature of IMC in the mixtures with PVP increases, and the amorphous state is preserved longer on storage. The mixtures were characterized by Raman spectroscopy. Dissolution of the IMC in the cryoground mixtures is higher as compared to the pure form, also after a prolonged storage.
- Subjects
INDOMETHACIN; DRUG development; POVIDONE; SIZE reduction of materials; LOW temperatures; CALORIMETRY; RAMAN spectroscopy
- Publication
Journal of Thermal Analysis & Calorimetry, 2007, Vol 89, Issue 3, p709
- ISSN
1388-6150
- Publication type
Article
- DOI
10.1007/s10973-006-7959-6