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- Title
Feasibility of a virtual reality intervention targeting distress and anxiety symptoms in patients with primary brain tumors: Interim analysis of a phase 2 clinical trial.
- Authors
King, Amanda L.; Roche, Kayla N.; Leeper, Heather E.; Vera, Elizabeth; Mendoza, Tito; Mentges, Kelly; Acquaye-Mallory, Alvina A.; Adegbesan, Kendra A.; Boris, Lisa; Burton, Eric; Choi, Anna; Grajkowska, Ewa; Kunst, Tricia; Levine, Jason; Lollo, Nicole; Miller, Hope; Panzer, Marissa; Penas-Prado, Marta; Pillai, Valentina; Polskin, Lily
- Abstract
Purpose: Cancer patients experience distress and anxiety when undergoing imaging studies to monitor disease status, yet these symptoms are not always appropriately identified or well-managed. This interim analysis of a phase 2 clinical trial explored feasibility and acceptability of a virtual reality relaxation (VR) intervention for primary brain tumor (PBT) patients at the time of clinical evaluation. Methods: English speaking, adult PBT patients with previous reports of distress and upcoming neuroimaging were recruited between March of 2021 and March 2022. A brief VR session was done within 2 weeks prior to neuroimaging with patient-reported outcomes (PROs) collected before and immediately post-intervention. Self-directed VR use over the next 1 month was encouraged with additional PROs assessments at 1 and 4 weeks. Feasibility metrics included enrollment, eligibility, attrition, and device-related adverse effects with satisfaction measured with qualitative phone interviews. Results: Fifty-five patients were approached via email, 40 (73%) responded and 20 (50%) enrolled (9 declines, 11 screen fails). 65% of participants were ≤ 50 years, 50% were male, 90% were White/non-Hispanic, 85% had good KPS (≥ 90), and most were on active treatment. All patients completed the VR intervention, PROs questionnaires, weekly check-ins, and qualitative interview. Most (90%) reported frequent VR use and high satisfaction and only 7 mild AEs were recorded (headache, dizziness, nausea, neck pain). Conclusion: This interim analysis supports feasibility and acceptability of a novel VR intervention to target psychological symptoms for PBT patients. Trial enrollment will continue to assess for intervention efficacy. Trial Registration: NCT04301089 registered on 3/9/2020.
- Subjects
BRAIN tumors; VIRTUAL reality; CLINICAL trials; PSYCHOTHERAPY; PSYCHOLOGICAL distress; SATISFACTION
- Publication
Journal of Neuro-Oncology, 2023, Vol 162, Issue 1, p137
- ISSN
0167-594X
- Publication type
Article
- DOI
10.1007/s11060-023-04271-0