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- Title
Etorphine-Related Ferrocenyl-Substituted Morphinan Alkaloids.
- Authors
Gerhard Laus; Johannes Schütz; Herwig Schottenberger; Max Andre; Klaus Wurst; Mariana Spetea; Karl-Hans Ongania; Adrian G. Müller; Helmut Schmidhammer
- Abstract
The two diastereoisomeric ferrocenyl-substituted orvinols 2 and 3 were prepared. The modified alkaloids are still able to interact with opioid receptors (see Table). The ferrocene moiety allows highly selective and sensitive electrochemical detection. The X-ray crystal structure of the major isomer 2 was determined. The combination of a metallocene and a morphinan alkaloid holds promise for useful antitumor activity.
- Subjects
STEREOISOMERS; ALKALOIDS; OPIOIDS; CRYSTALS
- Publication
Helvetica Chimica Acta, 2003, Vol 86, Issue 10, p3274
- ISSN
0018-019X
- Publication type
Article