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- Title
Haemorrhoids are related to changes of cell function in mucosa and submucosa.
- Authors
Klink, Christian; Binnebösel, Marcel; Kämmer, Daniel; Willis, Stefan; Prescher, Andreas; Klinge, Uwe; Schumpelick, Volker
- Abstract
Epidemiology and risk factors of haemorrhoidal disease are not well defined. This study tried to evaluate if the appearance of haemorrhoids is related to a disturbed remodelling of the soft tissue of rectal mucosa and submucosa. Therefore, immunohistochemical expression profiles of five parameters as potential mediators in neoangiogenesis ( EGFR), in inflammatory cell activity ( COX-2), and in cell migration, differentiation, and wound healing ( notch-3, c-myc, and ß-Catenin) were analysed (Saed et al., Fertil Steril 83(Suppl 1):1216–1219, ; Saed et al., Fertil Steril 79:1404–1408, ; Stojadinovic et al., Am J Pathol 167:59–69, ). Haemorrhoidal tissue specimens were collected from 44 patients. Healthy rectal mucosa was obtained from 16 non-fixed fresh cadavers and served as control. Histological and immunohistochemical markers like EGFR, COX-2, notch-3, c-myc, and ß-Catenin were analysed semi-quantitatively, separately for mucosal and submucosal layer. Significantly increased expressions were found for EGFR, COX-2, and notch-3 in the mucosal and submucosal layer of haemorrhoidal tissue in comparison to normal rectal tissue. This finding confirms that haemorrhoidal disease may be regarded as a manifestation of a soft tissue disease.
- Subjects
HEMORRHOIDS; MUCOUS membranes; RECTAL diseases; EXTRACELLULAR matrix; WOUND healing; DISEASE risk factors; EPIDEMIOLOGY
- Publication
International Journal of Colorectal Disease, 2009, Vol 24, Issue 12, p1389
- ISSN
0179-1958
- Publication type
Article
- DOI
10.1007/s00384-009-0768-1