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- Title
Genomic location and characterisation of MIC genes in cattle.
- Authors
Birch, James; De Juan Sanjuan, Cristina; Guzman, Efrain; Ellis, Shirley A.
- Abstract
Major histocompatibility complex ( MHC) class I chain-related ( MIC) genes have been previously identified and characterised in human. They encode polymorphic class I-like molecules that are stress-inducible, and constitute one of the ligands of the activating natural killer cell receptor NKG2D. We have identified three MIC genes within the cattle genome, located close to three non-classical MHC class I genes. The genomic position relative to other genes is very similar to the arrangement reported in the pig MHC region. Analysis of MIC cDNA sequences derived from a range of cattle cell lines suggest there may be four MIC genes in total. We have investigated the presence of the genes in distinct and well-defined MHC haplotypes, and show that one gene is consistently present, while configuration of the other three genes appears variable.
- Subjects
GENOMICS; MAJOR histocompatibility complex; GENES; GENETIC polymorphisms; GENOMES; CATTLE
- Publication
Immunogenetics, 2008, Vol 60, Issue 8, p477
- ISSN
0093-7711
- Publication type
Article
- DOI
10.1007/s00251-008-0306-2