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- Title
Human leukocyte antigen (HLA) phenotypes in siblings with osteosarcoma.
- Authors
Shinozaki, Tetsuya; Watanabe, Hideomi; Shimizu, Toru; Yanagawa, Takashi; Takagishi, Kenji
- Abstract
Osteosarcoma was detected in two siblings. Their human leukocyte antigen (HLA) phenotypes were completely identical, although they were different from those of osteosarcoma patients in previous reports. Despite an extensive search of family and past history, no significant background related to the induction of cancer could be found. These cases suggest that genetic similarity may influence the development of osteosarcoma. Ascertainment of the HLA phenotypes in siblings with osteosarcoma might be a useful strategy to facilitate the early diagnosis of this tumor.
- Subjects
HLA histocompatibility antigens; HISTOCOMPATIBILITY antigens; ISOANTIGENS; OSTEOSARCOMA; SARCOMA; BONE cancer; CHILDHOOD cancer; TUMORS in children
- Publication
Archives of Orthopaedic & Trauma Surgery, 2000, Vol 120, Issue 5/6, p343
- ISSN
0936-8051
- Publication type
Article
- DOI
10.1007/s004020050479