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- Title
Epigenetic profiling reveals a subset of pediatric-type glioneuronal tumors characterized by oncogenic gene fusions involving several targetable kinases.
- Authors
Sievers, Philipp; Sill, Martin; Schrimpf, Daniel; Friedel, Dennis; Sturm, Dominik; Gardberg, Maria; Kurian, Kathreena M.; Krskova, Lenka; Vicha, Ales; Schaller, Tina; Hagel, Christian; Abdullaev, Zied; Aldape, Kenneth; Jacques, Thomas S.; Korshunov, Andrey; Wick, Wolfgang; Pfister, Stefan M.; von Deimling, Andreas; Jones, David T. W.; Sahm, Felix
- Abstract
These data suggest a remarkably wide range of different gene fusions that drive tumors within this epigenetic group and in parallel highlights attractive therapeutic targets in particular for patients with incomplete surgical resection or tumor progressions. Given their morphological overlap with other GNTs and the lack of a pathognomonic alteration, we provisionally suggest the term "glioneuronal tumor kinase-fused" (GNT KinF A) to describe this novel group of tumors. To identify novel epigenetic subgroups of GNTs, we used an unsupervised visualization approach with a comprehensive dataset of DNA methylation profiles covering the entire spectrum of existing molecular CNS tumor classes [[2]].
- Subjects
GENE fusion; GENE expression profiling; KINASES
- Publication
Acta Neuropathologica, 2022, Vol 144, Issue 5, p1049
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/s00401-022-02492-7