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- Title
Prion protein gene polymorphism in four West African sheep populations.
- Authors
Traoré, Amadou; Royo, Luis; Kaboré, Adama; Pérez-Pardal, Lucía; Álvarez, Isabel; Fernández, Iván; Sawadogo, Laya; Tamboura, Hamidou; Goyache, Félix
- Abstract
A total of 162 individuals, belonging to three Burkinabé and one Niger sheep populations, were analysed for prion protein (PrP) gene polymorphism at codons 136, 154 and 171. The ARQ allele was the most frequent in both the Burkinabé (86.7%) and the Niger (67.5%) sheep populations. The highly sensitive allele VRQ was not found in the sampled individuals. The highly resistant ARR allele was in very low frequency in the Burkina-Sahel (4.4%) and Mossi (3.2%) populations and was not present in the Djallonké and Touareg populations. Only 4 out of 15 possible PrP genotypes were identified in the sampled individuals. No favourable ARR/ARR genotypes were found in either of the breeds. Sequencing a subgroup of the samples allowed the identification of other five polymorphisms on the PrP gene sequence at codons 116, 138, 151, 237 and 240. The very low frequency of the ARR allele in the West African sheep should dissuade the implementation of a preventive selection programme aimed to increase resistance to scrapie, to avoid an extreme erosion of the genetic stock.
- Subjects
WEST Africa; GENETIC polymorphisms; AMPLIFIED fragment length polymorphism; SCRAPIE; POLYMERASE chain reaction; SHEEP
- Publication
Tropical Animal Health & Production, 2012, Vol 44, Issue 7, p1469
- ISSN
0049-4747
- Publication type
Article
- DOI
10.1007/s11250-012-0088-2