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- Title
Gemcitabine Plus Vinorelbine as the Second-Line Treatment and Beyond in Elderly Patients with Platinum-Pretreated Advanced Non-Small Cell Lung Cancer.
- Authors
Go, Se-Il; Lee, Won Sup; Lee, Gyeong-Won; Kang, Jung Hun; Kang, Myoung Hee; Song, Haa-Na; Lee, Anna; Lee, Un Seok; Choi, Hye Jung; Kim, Hoon-Gu
- Abstract
Background: The efficacy and tolerance of a gemcitabine and vinorelbine (GV) combination as salvage therapy have not been reported in elderly patients with advanced non-small cell lung cancer (NSCLC). Methods: We reviewed elderly patients with advanced NSCLC who had disease progression after one or more chemotherapy regimens, at least one including platinum, and then who were treated with GV as the salvage therapy. Results: In total 40 patients were analyzed. GV was at least the third-line chemotherapy in 24 patients (60.0%). Only 2 patients (5.0%) experienced grade 3 febrile neutropenia. Nonhematologic toxicities were generally mild and there was no treatment-related mortality. Among 29 patients evaluable for treatment response, 10 (34.5%) and 9 (31.0%) achieved a partial response and stable disease, respectively. The median overall survival was 10.3 months and the median progression-free survival was 3.1 months. Conclusions: GV in combination is an effective and tolerable salvage regimen in elderly and heavily pretreated patients with advanced NSCLC. © 2015 S. Karger AG, Basel
- Subjects
VINORELBINE; OLDER patients; NON-small-cell lung carcinoma; DRUG efficacy; SALVAGE therapy; DISEASE progression; PHYSIOLOGICAL effects of platinum
- Publication
Chemotherapy (0009-3157), 2015, Vol 60, Issue 4, p267
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000381636