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- Title
A case–control study of response to lamivudine therapy for 2 years in Japanese and Chinese patients chronically infected with hepatitis B virus of genotypes Bj, Ba and C
- Authors
Orito, Etsuro; Fujiwara, Kei; Tanaka, Yasuhito; Yuen, Man-Fung; Lai, Ching-Lung; Kato, Takanobu; Sugauchi, Fuminaka; Kusakabe, Atsunori; Sata, Michio; Okanoue, Takeshi; Niitsuma, Hirofumi; Sakugawa, Hiroshi; Hasegawa, Izumi; Mizokami, Masashi
- Abstract
Abstract: Background/aims: In eastern Asian countries, hepatitis B virus (HBV) genotype Ba (HBV/Ba), HBV/Bj and HBV/C are prevalent. The aim was to investigate the response or resistance to lamivudine therapy among patients with different HBV genotypes. Methods: Of 67 Japanese and Chinese patients with chronic hepatitis B, 18 patients with HBV/Bj, 15 with HBV/Ba and 34 with HBV/C were selected for a case–control study matched according to gender and age. All the patients were treated with lamivudine for 2 years and evaluated the response or emergence of the YMDD mutation at year 2 during the treatment. HBV genotypes were detected by the restriction fragment length polymorphism. The YMDD mutation was detected by the direct sequencing after amplification by PCR. Results: At year 2 during therapy, 44.8% of the patients showed normalization of ALT and undetectable HBV DNA (favorable response), 35.8% developed the YMDD mutation. There was no significant difference of response to the therapy among the three genotype groups. The emergence of the YMDD mutation was associated with HBV/C. By the multiple logistic regression analysis, however, the significant factor of a favorable response was a higher pretreatment ALT level and negative HBeAg status and the significant factor of the emergence of the YMDD mutation was HBV/C. Conclusions: Higher pretreatment ALT level, HBeAg status or HBV genotype may affect the response or resistance to lamivudine therapy.
- Subjects
EAST Asia; HEPATITIS B virus; THERAPEUTICS; JAPANESE people; CHINESE people; DISEASES
- Publication
Hepatology Research, 2006, Vol 35, Issue 2, p127
- ISSN
1386-6346
- Publication type
Article
- DOI
10.1016/j.hepres.2006.03.005