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- Title
Genome editing in large animals: current status and future prospects.
- Authors
Zhao, Jianguo; Lai, Liangxue; Ji, Weizhi; Zhou, Qi
- Abstract
Large animals (non-human primates, livestock and dogs) are playing important roles in biomedical research, and large livestock animals serve as important sources of meat and milk. The recently developed programmable DNA nucleases have revolutionized the generation of gene-modified large animals that are used for biological and biomedical research. In this review, we briefly introduce the recent advances in nuclease-meditated gene editing tools, and we outline these editing tools' applications in human disease modeling, regenerative medicine and agriculture. Additionally, we provide perspectives regarding the challenges and prospects of the new genome editing technology.
- Subjects
GENOME editing; ORGANIC farming; REGENERATIVE medicine; MACAQUES; MEDICAL research; MEDICAL model; PROSPECTING
- Publication
National Science Review, 2019, Vol 6, Issue 3, p402
- ISSN
2095-5138
- Publication type
Article
- DOI
10.1093/nsr/nwz013