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- Title
Time‐dependent systolic blood pressure within 72 h after endovascular treatment in large vessel occlusion stroke.
- Authors
Jiang, Xin; Fang, Jinghuan; Gao, Lijie; Dong, Shuju; Wang, Jian; Hu, Fayun; He, Li
- Abstract
Background: The association of systolic blood pressure (SBP) and ischemic stroke outcome has recently been proved to be varied at different time points within 72 h after acute ischemic stroke onset; however, the specific status of how SBP affects prognosis at different time points within 72 h after endovascular treatment (EVT) among patients with large vessel occlusion (LVO) remains unclear. Methods: Consecutive LVO patients treated with EVT were enrolled in our study. BP data were collected at eight time points (1, 2, 4, 8, 16, 24, 48, and 72 h post‐EVT). Outcome measure of interest was functional dependence, which was defined as mRS >2 at 90 days. Results: A total of 406 LVO patients treated with EVT from 2016 to 2022 were included. At 16 h after EVT, the relationship between SBP and functional dependence showed a nonlinear association. At other time points after EVT, SBP had linear relationships with functional dependence. Furthermore, higher SBP, as either a linear or quadratic term, had an adverse effect on functional outcome. In addition, three SBP trajectories were observed, and the high‐to‐low group was independently associated with functional dependence. Conclusion: Taken together, higher SBP within the first 72 h after EVT has a time‐dependent association with adverse clinical outcomes. Optimal blood pressure management during the first 72 h after EVT may be important to improve clinical outcome.
- Subjects
SYSTOLIC blood pressure; ENDOVASCULAR surgery; STROKE; ISCHEMIC stroke; BLOOD pressure
- Publication
Brain & Behavior, 2024, Vol 14, Issue 3, p1
- ISSN
2162-3279
- Publication type
Article
- DOI
10.1002/brb3.3442