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- Title
Noninvasive MRI measurement of CBF: evaluating an arterial spin labelling sequence with <sup>99m</sup>Tc-HMPAO CBF autoradiography in a rat stroke model.
- Authors
Baskerville, Tracey A; McCabe, Christopher; Weir, Christopher J; Macrae, I Mhairi; Holmes, William M
- Abstract
Arterial spin labelling (ASL) is increasingly available for noninvasive cerebral blood flow (CBF) measurement in stroke research. Here, a pseudo-continuous ASL technique (pCASL) was evaluated against 99mTc-D, L-hexamethylpropyleneamine oxime (99mTc-HMPAO) autoradiography in a rat stroke model. The 99mTc-HMPAO was injected (intravenously, 225 MBq) during pCASL acquisition. The pCASL and 99mTc-HMPAO autoradiography CBF measures, relative to the contralateral hemisphere, were in good agreement across the spectrum of flow values in normal and ischemic tissues. The pCASL-derived quantitative regional CBF values (contralateral: 157 to 177 mL/100 g per minute; ipsilateral: 9 to 104 mL/100 g per minute) were consistent with the literature values. The data show the potential utility of pCASL for CBF assessment in a rat stroke model.
- Subjects
MAGNETIC resonance imaging; AUTORADIOGRAPHY; LABORATORY rats; CEREBRAL circulation; OXIMES; LITERATURE reviews
- Publication
Journal of Cerebral Blood Flow & Metabolism, 2012, Vol 32, Issue 6, p973
- ISSN
0271-678X
- Publication type
Article
- DOI
10.1038/jcbfm.2012.19