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- Title
Mycobacterium tuberculosis DNA in living donor transplanted livers and donor‐related tuberculosis in recipients: A retrospective longitudinal cohort study.
- Authors
Alrajhi, Abdulrahman A.; Alotaibi, Jawaher; Alghamdi, Ali M.; Almanea, Hadeel; AlSebayel, Mohammed; Al‐Meshari, Khalid; Al‐Hajoj, Sahal
- Abstract
Objectives: Mycobacterium tuberculosis DNA has been detected in multiple organs in people without active tuberculosis or a history of tuberculosis. Molecular testing for metabolic activity has suggested that M tuberculosis DNA represents viable bacilli. Whether transplanted organs with M tuberculosis DNA can result in tuberculosis in recipients has not been assessed. Methods: Biopsies obtained at the time of living donor liver transplantation were tested for the presence of M tuberculosis DNA using in situ PCR. The cohort of recipients was longitudinally followed for the development of tuberculosis. Results: Living donor liver transplantation was performed for 270 patients. Mean age was 33 years (median: 41 years, range: 1‐80 years). Recipients were followed for a mean of 68 months (median: 72 months, range: 1‐138 months) after transplantation. Mycobacterium tuberculosis DNA was detected in 25 of 155 donated livers (16%) with liver biopsies available for testing. None of the recipients of these livers received tuberculosis chemoprophylaxis and only one (4%) developed tuberculosis 15 months after transplantation. Among the entire cohort of 270 patients, post‐transplant tuberculosis was diagnosed in four patients (1.48%) at an incidence rate of 2.61 cases per 1000 transplant‐years. No factors associated with developing tuberculosis were identified, including positive M tuberculosis DNA in transplanted livers. Conclusions: Mycobacterium tuberculosis DNA in living donor transplanted livers did not result in tuberculosis despite post‐transplant immunosuppression.
- Subjects
MYCOBACTERIUM tuberculosis; TUBERCULOSIS; LIVER transplantation; DNA; COHORT analysis; ORGAN donor registries; ACTIVE aging
- Publication
Transplant Infectious Disease, 2020, Vol 22, Issue 1, p1
- ISSN
1398-2273
- Publication type
Article
- DOI
10.1111/tid.13212