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- Title
Garlic-induced Stable Black Gold Nanostructure: Optical, Morphological, Antibacterial, Antioxidant and Cytotoxic Properties.
- Authors
Ariyanta, Harits Atika; Nainggolan, Hotlina; Denti, Siti Aysah; M., Yega Segara; Setiyanto, Cahya Mukti; Ivandini, Tribidasari A.
- Abstract
We have successfully developed a direct, one-step phyto-synthesis of stable black gold nanostructure (AuNS) using garlic extract (GE). The presence of abundant S in GE has a high affinity for Au, forming strong Au-S bonds to induce the growth of anisotropic crystals on Au and continue to form an extensive network of nanowires resembling a dendrimer. The synthesized garlic-induced stable black AuNS was observed by a color change from brick-red to black through the addition of GE at various concentrations and confirmed by the UV-Vis spectrophotometer, particle size analyzer (PSA), transmission electron microscope (TEM), Fourier transform infrared (FTIR), and xray diffraction (XRD) spectrophotometer. In addition, the antibacterial, antioxidant, and cytotoxic properties of the black AuNS were studied. Black-AuNs showed no antibacterial activity on gramnegative bacteria (Escherichia coli) and two gram-positive bacteria (Staphylococcus aureus and Bacillus subtilisin) but had very high antioxidant activity (99.68% DPPH inhibition). The cytotoxic effect of black-AuNS was studied in normal cells and showed that the inhibition in both Vero and Chang cells was dose-dependent. These findings offer new opportunities to develop a "green" superstructure of black AuNS for other biomedical applications.
- Subjects
TRANSMISSION electron microscopes; ANISOTROPIC crystals; GRAM-positive bacteria; DENDRIMERS; X-ray diffraction; BACILLUS (Bacteria)
- Publication
International Journal of Technology, 2024, Vol 15, Issue 4, p965
- ISSN
2086-9614
- Publication type
Article
- DOI
10.14716/ijtech.v15i4.6147