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- Title
Tc-99m ile İşaretli Kurkumin Yüklü Katı Lipit Nanopartiküllerin Karaciğer-Dalak Sintigrafisindeki Rolü.
- Authors
EROGLU, Hayrettin; YENILMEZ, Ayşe; AYAN, Arif Kursad; GÜNDOĞDU, Cemal; ŞİPAL, Sare
- Abstract
Recently, nanotechnology and molecular imaging fields are integrated to facilitate the diagnosis and the treatment of diseases with create multi-functional nanoparticles. Nuclear medicine is one of the fields that benefit from the multi-faceted and unique characteristics of new generation imaging agents that are made of nanoparticles. This study investigated the feasibility of using curcumin-loaded SLNs in liver and spleen scintigraphy. Initially, the curcumin-loaded solid lipid nanoparticles (C-SLN) were prepared using microemulsion and solidification at low temperatures. The size of the C-SLN particle is measured by Laser diffraction (LD) method. Moreover, by applying thermogravimetric analysis (TGA) it is observed that C-SLN particles are stable with temperature variation. Then, they are radiolabeled with Technetium-99m (99mTc). Using the thin-layer chromatography method, the radiolabeling efficiency was found to be higher than 95%. 99mTc-C-SLNs were injected to the rabbit intravenously (i.v.) and using a gamma camera, dynamic images were recorded. Liver and spleen were clearly displayed in these dynamic images. In addition to scintigraphic findings, the presence of 99mTc-C-SLNs in the liver and the spleen was observed in the ex vivo biodistribution studies and the analyses performed under the fluorescence microscope.
- Publication
Journal of the Institute of Science & Technology / Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2016, Vol 6, Issue 3, p27
- ISSN
2146-0574
- Publication type
Article
- DOI
10.21597/jist.2016321836