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- Title
Effectiveness and predictors of weight loss response to phentermine plus lifestyle modifications among youth in a paediatric weight management clinical setting.
- Authors
Bomberg, Eric M.; Clark, Justin; Rudser, Kyle D.; Gross, Amy C.; Kelly, Aaron S.; Fox, Claudia K.
- Abstract
Summary: Background: Anti‐obesity medications (AOMs) are promising lifestyle modification (LSM) adjuncts for obesity treatment, and phentermine is commonly prescribed in paediatric weight management clinics. Determining 'real‐world' AOM effectiveness and characteristics predicting response is important. Objectives: We sought to describe phentermine plus LSM effectiveness and identify baseline characteristics predicting response. Methods: This was a retrospective cohort study among youth seen in a US academic‐based weight management clinic from 2012 to 2020. Baseline characteristics (e.g., body mass index (BMI), liver transaminases, eating‐related behaviours) and outcomes (%BMI of 95th percentile (%BMIp95), BMI, %BMI change, weight) were determined through electronic health records and intake surveys. Results: Among 91 youth prescribed phentermine plus LSM over 8 years (mean %BMIp95 150%), %BMIp95 was statistically significantly reduced at 1.5, 3, 6 and 12 months (peak reduction 10.9 percentage points at 6 months; p < 0.001). Considering multiple comparisons, the presence of baseline elevated alanine aminotransferase was associated with statistically significant smaller 1.5‐month %BMIp95 reductions (p = 0.001) and higher food responsiveness with smaller 3‐ (p = 0.001) and 6‐month (p < 0.001) reductions. Conclusions: Phentermine plus LSM reduced %BMIp95 among youth in a weight management clinic, and baseline characteristics may help determine those more or less likely to respond. Prospective studies are needed to further characterize effectiveness and confirm response predictors.
- Subjects
UNITED States; WEIGHT loss; BEHAVIOR modification; BODY mass index; RESEARCH funding; REGULATION of body weight; ASPARTATE aminotransferase; RETROSPECTIVE studies; DESCRIPTIVE statistics; LONGITUDINAL method; SURVEYS; ANTIOBESITY agents; HEALTH behavior; DRUG efficacy; FOOD habits; ELECTRONIC health records; CHILDHOOD obesity; EVALUATION
- Publication
Pediatric Obesity, 2024, Vol 19, Issue 8, p1
- ISSN
2047-6302
- Publication type
Article
- DOI
10.1111/ijpo.13143